12/1/2023 0 Comments Artisan hotel boutique![]() So we’ve created a list of the 12 best hotels in Philadelphia to help you plan your perfect getaway!ĭon’t forget to check out our web story: The 12 Best Boutique Hotels In PhiladelphiaĪs the fifth-largest city in the US, it’s no surprise that Philadelphia is home to a range of different neighborhoods. ![]() So many, in fact, that you might have a hard time choosing the perfect one. ![]() With its fascinating history and unique culture, it’s no surprise that Philadelphia is home to all sorts of luxurious historic hotels, industrial-chic apartment-hotels, and forward-thinking boutique hotels. If you want to get a boozy taste of the city – and learn about its Prohibition history along the way – just follow the Philadelphia Distillery Trail. The city is also home to tons of hip distilleries. From excellent Ethiopian eateries to authentic Thai restaurants, Philly has it all. And be sure to snap selfies at the “Rocky Steps” at the incredible Philadelphia Museum of Art and the famous LOVE sculpture at LOVE Park.Īfter you tick off the more popular Philadelphia attractions, you can have a picnic in the beautiful Rittenhouse Square, stroll along the bustling Delaware River waterfront, and marvel at iconic works of art at Barnes Foundation.įoodies should shop for local goods at the historic The Market at Reading Terminal, eat their way through The Italian Market, and sample the city’s incredibly diverse restaurant scene. If this is your first visit to the City of Brotherly Love, you’ll definitely want to meander the cobblestone streets of Independence Historic National Park and visit the Liberty Bell, Franklin Court, and Independence Hall. From its Revolutionary War history to its world-class museums to its innovative food and drink scene, there’s a lot to love about Philadelphia! Spend a few days exploring Pennsylvania’s largest city, and you’ll quickly see why more and more visitors are flocking here each year.
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12/1/2023 0 Comments Banned family guy episodes![]() If you see any of the following rules being broken, please report it to the mods here.Rachael MacFarlane Miss Tammy, Barbara, Waitress, Woman, Cheerleader, Fangirl, Girl in Commercial, Nurse, Olivia, Prostitute, Student, 1920s Woman, 911 Operator, Alexa, Amelia Bedelia, Animatronic Irish Woman, Answering Machine, Baby Elisabeth Hasselbeck, Beauty Academy Secretary, Becky, Beverly, Black Widow, Blonde Sitcom Mom, Bo Peep, Booze Cruiser, Brandy, Brian's Fan, British Woman, Britney Spears, Carrie, Catherine the Great, Cheerleader #3, Club Girl, College Girl, Decapitating Nun, Demagorgon's Wife, Dognapper, Dorothy Gale, Drone, Drug Den Announcer, Emma Stone, Farting Women, Female Bat, Female Mouse, Firehouse Girl, Focus Group Tester, French Woman, Front Desk Clerk, Future Quahog Mother, Girl, Girl #2 in Commercial, Girl #3, Girl Jumping From the Tree, Girlfriend, Grady Girls, Green Shirt Shopper, Heather, Helen Hunt, Hudson Comics Shopkeeper, Human Resources Manager, Ivanka Trump, Jacqueline, Jaimee, Jane Austen, Jayna, Jennifer, Jennifer Love Hewitt, Jennifer Schnozz, Jill, Joan of Arc, Kate, Kate Moss, Katie, Katie Couric, Kim Kardashian's Friend, Kitchen House Narrator, Lois Lane, Luke's Wife, Mad Men Producer, Madonna, Maid, Maid Madelaine, Mall Shopper, Marie Osmond, Marina Oswald, Mary Steenburgen, Mayor West's Secretary, Meat Customer, Meg Griffin, Meg's Friend, Minnie Mouse, Mom, Mom Group Leader, Monica, Mother, Mother of Young Boy, Mrs. Remember, all actions are at moderator discretion!įor more details on these rules, see here. No vote brigading - This includes inciting it as well. Posts may be removed on mod discretion.Ĭriticism of the show is allowed, but pointless shit posts/comments about the show without discussion or validity will result in an automatic ban.
12/1/2023 0 Comments Anti mog prognosis![]() Rempe’s study showed that compared with NMOSD patients, MOGAD patients with ON were more prone to bilateral optic nerve involvement (6/11 vs. Symptom Featuresīilateral involvement of the ON is usually present, but sometimes it may be unilateral ON ( Akaishi et al., 2019 Rempe et al., 2021). However, that study was very small and lacked sufficient statistical power. (2014) showed that among 9 MOGAD patients, none were diagnosed with ON alone, and 4 patients were diagnosed with ON plus myelitis simultaneously or successively. Significantly, retrospective analysis results of Kitley et al. Other studies have reported similar results ( Cobo-Calvo et al., 2017, 2021 Li et al., 2021 Rempe et al., 2021). ![]() ![]() (2020) analysis of 263 CNS demyelination episodes in 93 MOGAD patients showed that 121 (45.8%) were ON. Compared with patients with MS or NMOSD, those with MOGAD present with isolated ON without additional CNS lesions ( Wingerchuk et al., 2015). (2019) found that out of 166 MOGAD episodes in 85 patients, 67.5% were ON (bilateral neuritis was 18.7%). (2020) prospectively observed 65 patients diagnosed with acute ON within 1 year, 14% of whom were MOG-IgG positive. Optic neuritis (ON) is the most common symptom of MOGAD in adults, occurring in approximately 54-61% of patients ( Biotti et al., 2017 Hacohen et al., 2017 Cobo-Calvo et al., 2018 Carandini et al., 2021 Kunchok et al., 2021b). This paper discusses the typical symptoms and atypical symptoms of MOGAD through literature retrieval to improve the ability to identify potential patients. Many atypical symptoms or complications have been reported ( Fujimori et al., 2021 Peters et al., 2021 Wildemann et al., 2021). Additionally, there is no unified standard regarding the clinical manifestations and magnetic resonance imaging (MRI) characteristics of MOGAD. Although the specific pathophysiologic mechanism remains inconclusive, MOGAD usually manifests as direct demyelinating pathological changes that are similar to MS, unlike NMOSD, in which astrocytes are first damaged and then demyelinated ( Salama et al., 2019 Mader et al., 2020). Typical symptoms of MOGAD include ON and myelitis, which overlap with multiple sclerosis (MS) and NMOSD ( Carandini et al., 2021). MOGAD is a demyelinating disease of the central nervous system (CNS). With the popularization of cell-based assay detection methods, MOGAD has been separated from NMOSD ( Wingerchuk et al., 2015 Thompson et al., 2018). ( Fujimori et al., 2021 Peters et al., 2021 Wildemann et al., 2021). MOG-IgG can lead to ON, myelitis, and ADEM and are currently associated with anti-n-methyl-d-aspartate (NMADA) antibody encephalitis, teratoma, COVID-19, etc. Myelin oligodendrocyte glycoprotein (MOG) is widely present on the surface of oligodendrocytes and the myelin sheath of the nervous system, and its role may be similar to that of a cell adhesion molecule, maintaining the stability of the surface of oligodendrocytes and regulating the complement response ( Bernard et al., 1997 Johns and Bernard, 1999). The purpose of this review is to discuss the clinical manifestations, imaging features, outcomes and prognosis of MOGAD. Currently, there is a lack of clinical randomized controlled trials on the treatment and prognosis of MOGAD. Approximately 44-83% of patients undergo relapsing episodes within 8 months, which mostly involve the optic nerve, and persistently observed MOG-IgG and severe clinical performance may indicate a polyphasic course of illness. Compared to NMOSD, MOGAD generally responds well to immunotherapy and has a good functional prognosis. Attention should be given to screening patients with atypical symptoms. Some studies have revealed the presence of brainstem lesions, encephalopathy or cortical encephalitis. MOG-IgG have been found in patients with peripheral neuropathy, teratoma, COVID-19 pneumonia, etc. Usually, optic neuritis (ON), myelitis or acute disseminated encephalomyelitis (ADEM) encephalitis are the typical symptoms of MOGAD. MOGAD occurs in approximately the fourth decade of a person’s life without a markedly female predominance. In one study, 31% of NMOSD patients with negative aquaporin-4 (AQP-4) antibody were MOG-IgG positive. The detection of MOG-IgG has been greatly improved by the cell-based assay test method. Myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is a nervous system (NS) demyelination disease and a newly recognized distinct disease complicated with various diseases or symptoms however, MOGAD was once considered a subset of neuromyelitis optica spectrum disorder (NMOSD). Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Yunjie Li Xia Liu Jingxuan Wang Chao Pan * Zhouping Tang * 12/1/2023 0 Comments Butter vanilla flavoring![]() The plant effectively implemented changes reducing air concentrations of diacetyl by 1 to 3 orders of magnitude in the years following. Follow up investigations at the plant revealed that 25% of employees had abnormal spirometry exams. NIOSH investigated the worksite and suggested that artificial butter flavoring containing diacetyl was the most likely causative agent for the cases of bronchiolitis obliterans. Many of these individuals had initially been misdiagnosed as having other pulmonary diseases such as COPD and asthma. In the year 2000, eight cases of bronchiolitis obliterans were detected in former employees of a microwave popcorn plant. People who work with flavorings that include diacetyl are at risk for flavorings-related lung disease, including those who work in popcorn factories, restaurants, other snack food factories, bakeries, candy factories, margarine and cooking spread factories, and coffee processing facilities. It has also been called "flavorings-related bronchiolitis obliterans" or diacetyl-induced bronchiolitis obliterans. The disease has been called "popcorn worker's lung" or "popcorn lung" because it was first seen in former workers of a microwave popcorn factory in Missouri, but NIOSH refers to it by the more general term "flavorings-related lung disease". Workers in several factories that manufacture artificial butter flavoring have been diagnosed with bronchiolitis obliterans, a rare and serious disease of the lungs. The lung disease bronchiolitis obliterans is attributed to prolonged exposure to diacetyl, e.g. Manufacturers of margarines or similar oil-based products typically add it (along with beta carotene for the yellow color) to make the final product butter-flavored, because it would otherwise be relatively tasteless. It may contain diacetyl, acetylpropionyl, or acetoin, three natural compounds in butter that contribute to its characteristic taste and smell. If you’re looking for more mix in ideas, I suggest coconut milk and shredded coconut.Culinary liquid mimicking flavor of butterīutter-Vanilla flavor, a combination of butter flavor and vanilla flavorĪrtificial butter flavoring is a flavoring used to give a food the taste and smell of butter. So what do think? Pretty easy, right? Banana ice cream will satisfy your dessert craving in minutes. Peanut butter banana oatmeal bars are a healthy twist on a dessert bar.Chocolate chip banana oatmeal cookies have a subtle banana flavor and melted chocolate chips throughout. ![]() Banana cinnamon muffins are easy to make from scratch and filled with cinnamon flavor.Moist banana bread is made with ripe bananas and melted butter for the best taste and texture.More banana recipesĭo you love bananas? Or have a ton of ripe bananas in the house? Give these recipes a try! ![]() If you don’t have either, you can wait for the bananas to defrost and combine the ingredients with an electric mixer, but the ice cream won’t be as smooth. For hard ice cream consistency, freeze for 1 hour.Ĭan I make this ice cream without a food processor? Yes, a blender is the next best bet.
12/1/2023 0 Comments Best things to do in dallas texasHead over to Globe Life Park in Arlington, home to the Texas Rangers (tickets as low as $11) or to Dr. Teams representing every major professional sports’ league call Dallas home.Ĩ. If you like sports, Dallas has you covered. Don’t feel like walking all the way or going it alone? Take the historic Segway tour. Walk around downtown Fort Worth, do some window shopping and people watching, then stroll to the Water Gardens to cool off in the architectural marvel. Sundance Square and the Fort Worth Water Gardens (Free). ![]() Admission is only $2 for adults and kids are free.ħ. The museum is open from 10a to 5p every day (closed on Sundays). Learn the history of the stockyards and explore the exhibits, collections, and artifacts. Garcia’s to sit on their gorgeous patio and chow down on some of the best TexMex you’ll ever have.Ħ. Shop for some real Texas cowboy gear or a Texas-sized souvenir while strolling through the downtown square. But wait! There is lots more to do while you’re there. Watch the world’s only twice-daily cattle drive, held every day at 11:30a and 4:00p. Track the trolley and donate at: Fort Worthĥ. Trolley is free donations greatly appreciated. M-Line service operates seven days a week. This nostalgic streetcar will take you from the downtown Dallas Arts District to trendy shops and restaurants in Uptown, to a stop at Klyde Warren Park. If you’re looking to do some sightseeing downtown, the best and most fun way to go about it is to take a spin on the M Line Vintage Trolley (Free). Cloud Nine rotates during lunch and Five Sixty rotates nightly beginning at 5p.Ĥ. While you’re there, enjoy a snack at the Cloud Nine Cafe or fine dining at Five Sixty by Wolfgang Puck. Admission is included with the Dallas CityPASS or you can buy tickets starting at $17 for adults and $8 for children ages 4 to 12. The Reunion Tower GeO-Deck offers incredible views of Dallas from its observation deck. While at the park, you can participate in four to five activities every day, making any time a fun time to visit the park! Some activities include a FREE games area, food trucks from 11a – 4p, walking trails, a dog park, a children’s playground, and a performance pavilion.ģ. Another must see in the downtown area is Klyde Warren Park (Free). From there you can head over to the highly recommended Sixth Floor Museum ($18), which includes a view from Oswald’s supposed shooting location.Ģ. Located in the West End district of downtown Dallas, this is the location of the assassination of John F. See the historic Dealey Plaza and the Grassy Knoll (Free). It offers rental cars by the hour or day, with gas and insurance included, for one low price. ZipCar is another option that gives you flexibility. A bonus is that you’ll save money by not paying for parking at each location you visit. If you’re uncomfortable driving around or want to keep your car at the hotel, consider taking an Uber or Lyft between attractions. Each price is very reasonable (under $10), and the rides themselves are fun and allow you to take in the local scenery. The Trinity Railroad Express (TRE) runs between Fort Worth to Dallas (DFW Airport is a stop!), and there is the DART which runs from downtown Dallas up Interstate 75 to the suburb of Plano. ![]() There are a couple of train lines if you’re going to be in the select areas they travel. While there is some public transportation, you won’t want to rely on it solely to get you everywhere you’re going to want to go. Getting Around Dallasĭid you know that over 7 million people live in the Dallas metroplex? It’s safe to say that this is a BIG city. You can also grab the DART into downtown for $3 but first, you’ll have to ride the free Love Link bus to the DART station.Ĭheck out Travelocity and Cheap O Air for some great deals to Dallas. An Uber from Love Field to downtown will be about $15. ![]() Love Field is only six miles outside downtown Dallas and is heavily serviced by Southwest airlines, meaning lots of discount domestic flights. Public transportation is also an option the DART will get you downtown in about an hour and will only set you back $3. Getting an Uber to downtown Dallas will take about 20 mins (traffic permitting) and cost you about $35. It’s also the hub of American Airlines, so finding a convenient flight is rarely an issue. Worth International Airport (DFW) and Love Field (DAL).ĭFW is located about 20 miles outside of Dallas and is one of the busiest airlines in the world.
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